What is the risk associated with applying a Tourniquet for more than 6 hours?

When a tourniquet is applied for more than six hours, the risk of amputation significantly increases due to the prolonged restriction of blood flow to the tissues. The extended duration can lead to ischemic injury, where cells and tissues begin to die from lack of oxygen and nutrients, ultimately compromising their viability. If the affected limb suffers severe necrosis or irreversible damage, medical professionals may have no option but to amputate to prevent systemic complications, such as sepsis, that can arise from dead or dying tissue.

While there are other risks associated with prolonged tourniquet use, such as potential for infection and effects of blood loss, the most direct and severe consequence after this time frame is the likelihood of amputation. Thus, timely removal or loosening of the tourniquet, when deemed safe, is crucial to preserve limb functionality and overall viability.