What is the recommended dosage of Naloxone for treating opioid overdose?

The recommended dosage of Naloxone for treating opioid overdose is indeed 0.4–2 mg. This range is considered effective for reversing the effects of opioids, including respiratory depression, which can be life-threatening in cases of overdose. Naloxone can be administered intranasally or intramuscularly, and if the desired response is not achieved, doses can be repeated every 2 to 3 minutes, up to a total of 10 mg if necessary.

This dosage is based on clinical guidelines and has been widely adopted in emergency care settings. Other dosages listed in the choices do not align with the commonly recommended protocols for Naloxone administration in the treatment of opioid overdoses. For instance, higher dosages can lead to unnecessary complications or can cause withdrawal symptoms in individuals who are opioid-dependent. Thus, the specified range of 0.4–2 mg provides a safe and effective starting point in the emergency treatment of opioid overdose situations.